Chidamide

Catalog #

27202

$120 *

Size: 1 mg

Qty

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Description

Chidamide is a histone deacetylase inhibitor which increases Histone H3 acetylation levels in LoVo and HT29 colon cancer cells at low concentrations (4 µM). Chidamide affects the activation of oncogenic signaling kinases by dose-dependently reducing phosphorylated Akt, mTOR, p70S6K, Raf and Erk 1/2 protein expression in colon cancer cells. Chidamide also dose-dependently upregulates p21 protein expression, down-regulates CDK4, and induces cell cycle arrest at the G0/G1 phase.

This product has been cited 1 time.

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Product Info

Storage and Usage

Citations1

Purity

≥98% by HPLC.

Format

White to off-white crystalline solid.

Formula

C₂₂H₁₉FN₄O₂

390.4 Da

Solubility

Soluble in DMSO and DMF. Sparingly soluble in aqueous buffers. For maximum solubility, dissolve first in DMSO and then dilute with aqueous buffer of choice.

Biological Activity

Chidamide has shown an IC50 ranging from 1 – 13 µM using an MTT assay performed on human cancer cell lines.

CAS Registry #

743420-02-2

References

1. Liu, L., et al., Biochem. Biophys. Res. Commun. 2010; 392: 190-195.
2. Wang, H., et al., Mol Med Report. 2012 Apr 5. doi: 10.3892/mmr.2012.858. [Epub ahead of print]

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