CBHA

Catalog #

27204

$150 *

Size: 5 mg

Qty

Bulk/Custom

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Description

M-Carboxycinnamic Acid bishydroxamide, or CBHA, is a potent histone deacetylase (HDAC) inhibitor. CBHA has been found to induce apoptosis in nine different neuroblastoma cell lines in culture. It can also completely suppress neuroblastoma tumor growth in SCID mice at 200 mg/kg.

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Synonyms

M-Carboxycinnamic Acid bishydroxamide, CBHA

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Format

A crystalline solid

Formula

C₁₀H₁₀N₂O₄

222.2 Da

Solubility

Soluble in DMSO and DMF at 20 mg/ml. First, dissolve in DMSO then dilute with the aqueous buffer of choice.

Biological Activity

CBHA exhibits an IC50 of 0.01 µM and 0.07 µM in vitro for HDAC1 and HDAC3 respectively.

CAS Registry #

174664-65-4

References

1. Richon, V.M., et al., Proc. Natl. Acad. Sci. 1998; 95: 3003 – 3007.
2. Glick, R.D., et al., Cancer Res. 1999; 59: 4392 – 4399.
3. Coffey, D.C., et al., Cancer Res. 2001; 61: 3591 – 3594.

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