4-iodo-SAHA
Catalog #
27205
$155
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Description
4-iodo-SAHA is a hydrophobic derivative of SAHA, a class I and class II histone deacetylase (HDAC) inhibitor. Similar to SAHA, it demonstrates > 60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay at 1 µM.
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Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Format
A crystalline solid
Formula
C14H19IN2O3
MW
390.2 Da
Solubility
Solubility in ethanol is 0.2 mg/ml and 30 mg/ml in DMSO and DMF. First, dissolve in DMSO then dilute with the aqueous buffer of choice.
Biological Activity
4-iodo-SAHA inhibits SKBR3 breast-derived and HT29 colon-derived cell line proliferation with EC50 values comparable to that of SAHA (1.1 µM and 0.95 µM versus 2.1 µM and 2 µM, respectively). It has 10 times the inhibition strength of U937 leukemia cell proliferation in comparison to SAHA (0.12 µM versus 1.2 µM, respectively).
CAS Registry #
1219807-87-0
References
Salmi-Smail, C., et al., J. Med. Chem. 2010; 53: 3038 – 3047.
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