NcoR2 (SMRT), GST-tag

Catalog #: 50020
Size: 50 µg
$410
Species: Human
Host Species: E. coli
MW: 39 kDa
Genbank #: NM_006312
Tag(s): N-terminal GST-tag
a.a: 395–489
Background:
NcoR2 , nuclear receptor corepressor, are transcriptional corepressors that play an essential role in the regulation of development and metabolism. The interaction of HDAC3 with the deacetylase activation domain , DAD, of NCOR2/SMRT is required for activation of the otherwise inert deacetylase.
Description:
Human NCOR2/SMRT, DAD domain, a.a. 395-489, GenBank Accession No. NM_006312, N-terminal GST-tag, MW= 39 kDa, expressed in E. coli system. Source: E. coli. Purity: > 60% by SDS-PAGE.
UniProt
Q9Y618
Synonym(s):
nuclear receptor corepressor 2, Silencing mediator of retinoic acid and thyroid hormone receptor, TRAC-1, SMRT, NcoR2
Formulation:
50 mM Tris-HCl, pH 8.0, 138 mM NaCl, 20 mM glutathione, and 10% glycerol.
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
Codina, A. et al., Proc. Natl. Acad. Sci. USA, 102, 6009-6014, (2005)
Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Deacetylase
Product Type:
Recombinant Protein
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