HDAC11

Catalog #: 50021
Size: 10 µg
$425
Species: human
Host Species: Sf9 insect cells
MW: 39.6 kDa
Genbank #: NM_024827
Tag(s): none
a.a: full length
Description:
Human HDAC11 (full length) (GenBank Accession No. NM_024827) untagged, MW= 39.6 kDa, expressed in baculovirus expression system.
UniProt
Q96DB2
Synonym(s):
histone deacetylase 11, HDAC-11
Specific Activity:
≥ 1500 pmol/min/µg
Assay Conditions:
25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 0.05% Triton X-100, 0.1 mg/ml BSA, 20 µM BPS HDAC substrate 1 (Catalog #50040), and HDAC11 (0.4 – 25 ng). Incubation condition: 30 min at 37ºC followed by developing for 15 min at room temperature.
Formulation:
50 mM Tris-HCl, pH 8.0, 500 mM NaCl, 50 mM KCl, 2 mM EDTA, 3 mM DTT, 0.5% Triton-X-100 and 10% Glycerol.
Format:
Aqueous buffer solution
Storage / Stability:

>6 months at -80°C

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002).

Application Reference:
Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents (2014)

Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Deacetylase
Product Type:
Recombinant Protein
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Product Datasheets

50021_Lot141104.pdf