DCAMKL2, GST-tag Recombinant

Catalog #

40048

$410 *

Size: 10 µg

Qty

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Description

Recombinant human DCAMKL2 (a.a. 1-690), with N-terminal GST-tag, expressed by baculovirus in Sf9 cells

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Synonyms

DCLK2; DCK2; DCDC3; DCDC3B; DKFZp761I032; MGC45428

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

105 kDa

Amino Acids

1–690

Genbank #

NM_001040261

UniProt #

Q8N568

Tag(s)

N-terminal GST-tag

Background

DCAMKL2 (also known as doublecortin-like kinase 2 or DCLK2) is a close homologue of doublecortin or DCX which is associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly. DCX; DCLK2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. DCX and DCLK2 are co-expressed in developing hippocampus, and, in their absence, there is dosage-dependent disrupted hippocampal lamination associated with a cell-autonomous simplification of pyramidal dendritic arborizations leading to reduced inhibitory synaptic tone (1).

References

Kerjan G. Et al: Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6766-71.

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DCAMKL2, GST-tag Recombinant

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