Cyclopamine, Free Base
Catalog #
27013
$130
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Description
Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to induce apoptosis in colorectal adenoma cell lines, carcinoma-derived cell lines, and skin basal cell carcinomas and is being investigated as an anti-cancer drug.
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Product Info
Storage and Usage
Citations
Purity
≥99% by HPLC
Format
White to off-white crystalline solid
Formula
C27H41NO2
MW
411.6 Da
Solubility
Soluble in ethanol, methanol and DMSO. Ethanol is the best solvent for biological use. To make a 2% solution, heat cyclopamine in ethanol to 50-60°C. In methanol or DMSO, solubility is 7 mg/ml and 4 mg/ml respectively.
Biological Activity
Cyclopamine inhibits the activity for Hedgehog signaling-dependent motor neuron differentiation with IC50 = 300 nmol/L.
CAS Registry #
4449-51-8.
References
1. Taipale, J., et al., Nature 2000; 406: 944 – 945.
2. Chen, J.K., et al., Genes & Dev. 2002; 16: 2743 – 2748.
3. Qualtrough, D., et al., Int J Cancer. 2004; 110: 831-837.
2. Chen, J.K., et al., Genes & Dev. 2002; 16: 2743 – 2748.
3. Qualtrough, D., et al., Int J Cancer. 2004; 110: 831-837.
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