CUDC-907
Catalog #
27616-1
$235
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Description
CUDC-907 is a dual PI3K and HDAC inhibitor
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Synonyms
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Target(s)
HDAC, PI3K
Formula
C23H24N8O4S
MW
508.6 Da
Solubility
Soluble in DMSO
Biological Activity
CUDC-907 inhibits HDAC1, 2, 3, 6, 8, 10, and 11 with IC50 of 1.7 nM, 5 nM, 1.8 nM, 27 nM, 191 nM, 2.8 nM, and 5.4 nM, respectively. CUDC-907 inhibits PI3Kα (IC50 of 19 nM) and other PI3K isoforms such as PI3Kβ, PI3Kγ, PI3Kδ, PI3KαH1047R and PI3KαE545K with IC50 of 54 nM, 311 nM, 39 nM, 73 nM and 62 nM, respectively. CUDC-907 suppresses other types of HDAC enzymatic activity with lower potency.
CAS Registry #
1339928-25-4
Background
CUDC-907 has a long half-life in murine tumors. CUDC-907 induces apoptosis and inhibits cancer cell proliferation in xenograft tumors.
References
Qian C, et al. Clin Cancer Res. 2012 Aug 1;18(15):4104-13.
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