Anti-CTLA4 Neutralizing Antibody

Catalog #: 71212
Size: 100 µg
$445
Species: Human
Host Species: Freestyle 293 cells
MW: 150 kDa
Isotype: IgG1κ
Description:

Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of CTLA4 and blocking binding of CTLA4 to B7.1 and B7.2. This antibody has not been tested for cross-reactivity with other species.

Synonym(s):
Cytotoxic T-lymphocyte-associated protein 4, CD152
Endotoxin Level:
<1 EU/µg
Specific Activity:
IC50 = 5 nM
Assay Conditions:
Antibody was added to CTLA4:B7.1 binding assay at various concentrations. Assay was done according to BPS Cat. #72009 protocol.
Formulation:
8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Purification:
Protein A affinity chromatography from HEK293 supernatants.
Format:
Aqueous buffer solution.
Storage / Stability:
Stable for at least 12 months at -80°C.
Application(s):
Useful for inhibition of CTLA4:B7 interactions.
Reference(s):
1. Linsley, P.S., et al., J. Exp. Med. 1991; 174(3): 561-569.
2. Hurwitz, A.A., et al., Canc. Res. 2000; 60: 2444-2448.

Warning(s):
Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Scientific Category:
Immunotherapy
Product Type:
Antibody
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Product Datasheets

71212 Lot 160803.pdf