Cisplatin

Catalog #

27744

$165 *

Size: 5 mg

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Description

Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.

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Synonyms

CDDP; azane; dichloroplatinum(2+)

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Product Info

Storage and Usage

Citations

Formula

Cl₂H₆N₂Pt

300.1 Da

Solubility

Soluble in DMSO

CAS Registry #

15663-27-1

Background

Cisplatin induces cytotoxicity by interaction with DNA to form intrastrand crosslinks which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. Stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-?B content and translocation in macrophages.

References

1. Seki et al (2000). Cancer Chemother.Pharmacol. 45 199.
2. Duan et al (2004). Clin.Cancer Res. 10 234.
2. Nomura et al (2004). Urol.Oncology 22 453.

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Cisplatin

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