Cholesterol-Related Proteins


PCSK9 is a critical regulator of cholesterol metabolism through its interaction with the hepatic LDL receptor (LDLR). PCSK9 is a kexin (that is,an endopeptidase) found in kidneys, liver, and intestine.  It binds to the EGFR-like domain of LDLR, leading to LDLR degradation. Circulating PCSK9 binds to the extracellular EGF-like domain of LDLR, followed by endocytosis and lysosomal degradation of the PCSK9-LDLR complex. Inhibiting the PCSK9-LDLR interaction is an increasingly desirable drug target for lowering LDL-cholesterol levels because of the great demand for new drugs to replace or supplement statins.  The newly added research tools are invaluable for studying cholesterol metabolism, atherosclerosis, stroke, heart disease, and other diseases related to cardiovascular disorders. Specifically, BPS' PCSK9 neutralizing antibody, useful as a positive control for inhibition. 

BPS Bioscience offers PCSK9 and LDLR proteins, Binding Assay Kits, and PCSK9 Screening/Profiling Services for cholesterol related research. Interested in high throughput screening? Our PCSK9 assay kit is also available in a convenient, homogeneous TR-FRET format. Check this out along with the mutant (D374T) PCSK9 protein and mutant (D374T) PCSK9 assay kit which causes increased affinity of PCSK9 for the LDLR substrate.

Want to advance your project to the next level? Take a look at our PCSK9 Screening and Profiling Services.

19 Item(s)

per page

Catalog#SizeProduct NamePrice
33298 4 ml 3x PCSK9 TR-FRET Assay Buffer
$100
71207 50 µg Anti-PCSK9 Neutralizing Antibody
$455
71216 50 µg Anti-PCSK9 Neutralizing Antibody, Biotin-labeled
$500
71206 20 µg LDLR, Biotin-labeled
$460
71222 50 µg LDLR, FLAG-Avi-Tag (Mouse)
$425
71205 50 µg LDLR, FLAG-tag
$435
71208 20 µg MYLIP/IDOL, His-FLAG-tag
$450
71211 20 µg PCSK9(D374T), Biotin-labeled
$460
72011 384 reactions PCSK9(D374T)-LDLR TR-FRET Assay Kit
$725
71305 50 µg PCSK9, C-terminal Avi-His, Biotin-labeled
$405
71304 50 µg PCSK9, C-terminal His-Avi, Biotin-labeled
$405
71221-1 20 µg PCSK9, His-Avi-Tag (Mouse)
$245
71221-2 50 µg PCSK9, His-Avi-Tag (Mouse)
$425
71220-1 20 µg PCSK9, His-Avi-Tag (Rat)
$245
71220-2 50 µg PCSK9, His-Avi-Tag (Rat)
$425
71204-1 20 µg PCSK9, His-tag
$250
71204-2 50 µg PCSK9, His-tag
$435
72010 384 reactions PCSK9-LDLR TR-FRET Assay Kit
$725
72002 96 reactions PCSK9[Biotinylated]-LDLR Binding Assay Kit
$640

19 Item(s)

per page