CHK1, GST-tag Recombinant

Catalog #
40039
$410 *
Size: 10 µg
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Description

Recombinant full-length human CHK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_001274.

This product has been cited 1 time.

Synonyms
CHEK1, Checkpoint kinase 1
Product Info
Storage and Usage
Citations1
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥95%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
82 kDa
Amino Acids
full length
Specific Activity
214 pmol/min/µg
Genbank #
NM_001274
UniProt #
O14757
Tag(s)
N-terminal GST-tag
Background
CHK1 is a 56 kd serine/threonine protein kinase that was originally identified in fission yeast to play a role in activation of the DNA damage checkpoint in the G2 phase of the cell cycle (1). CHK1 appears to function downstream of several of the known fission yeast checkpoint gene products, including that encoded by rad3+, a gene with sequence similarity to the ATM gene mutated in patients with ataxia telangiectasia (2).
References
1. Walworth, N. et al. Nature. 1993 May 27,363(6427):368-71.
2. Walworth, NC. et al. Science. 1996 Jan 19,271(5247):353-6.