Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
71126 50 µg Frizzled-4, Fc fusion
$315
71139 50 µg Frizzled-7, Fc Fusion
$315
71172 100 µg GITR (CD357), Fc fusion (Human) HiP™
$310
71256 50 ug GITR (CD357), Fc Fusion, Biotin-labeled (Human)
$420
72061 96 reactions GITRL:GITR[Biotinylated] Inhibitor Screening Assay Kit
$1,040
71260 100 ug GPC3, His-tag [Monkey (M. fascicularis)]
$310
71112 100 µg Human LTBR, Fc fusion HiP™
$300
71142 100 µg HVEM, Fc fusion (Human)
$310
71143 50 µg HVEM, Fc fusion, Biotin-labeled (Human)
$420
71179 100 µg ICOS (CD278), Fc fusion (Human)
$310
90330 2 vials IKCA1 (KCNN4) - HEK293 Recombinant Cell Line
$7,500
91013-1 5 μg IL-17RA, Fc fusion, Biotin-labeled (Human)
$125
91013-2 25 μg IL-17RA, Fc fusion, Biotin-labeled (Human)
$315
72060 96 reactions IL-17RA[Biotin]:IL-17A Inhibitor Screening Assay Kit
$1,095
71298 50 μg KIR2DL3, Fc fusion, Biotin-labeled (Human)
$420
79050 100 µg LAG3 (CD223) (Mouse), Fc fusion (Human) Avi-Tag
$310
79003 50 µg LAG3 (CD223) (Mouse), Fc(Human) Avi-Tag, Biotin HiP™
$420
71147 50 µg LAG3 (CD223), Biotin-labeled (Human) HiP™
$420
71146 100 µg

LAG3 (CD223), Fc fusion (Human)
$310
71229 50 µg

LAG3, His-Tag, HiP™
$310
79483 100 μg LAIR1, Avi-His-Tag HiP™
$310
71206 20 µg LDLR, Biotin-labeled
$460
71222 50 µg LDLR, FLAG-Avi-Tag (Mouse)
$425
71205 50 µg LDLR, FLAG-tag
$435
79473 100 μg LILRB1, Fc-Fusion (IgG1), Avi-Tag HiP™
$310

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