Cell Surface Receptor(s)

 

Cell surface receptors, often called transmembrane receptors, are important proteins that mediate communication between the cell and the outside world. Extracellular ligands (cytokines, growth factors, hormones, neurotransmitters, or cell recognition molecules) bind to the receptor, triggering conformational changes that initiate intracellular signaling pathways (signal transduction). Cell surface receptors regulate a multitude of biological pathways required for cell growth, differentiation, proliferation, and survival.

Because of the critical nature of these pathways, it is not surprising that mutations in cell surface receptors are responsible for a wide array of diseases, including cancers, neurodegeneration, achondroplasia and atherosclerosis. In fact, nearly half of all drugs in clinical use target cell surface receptors, and these proteins and their ligands remain extremely important targets for structure-based drug design and novel drug development.

Cell Surface Receptors are divided into 3 major classes: ion channel-linked receptors, enzyme-linked receptors, and G protein-coupled receptors.

Ion channels are pore-forming proteins present in the membranes of all cells. Ions pass through channels down their electrochemical gradient, without the requirement for ATP or metabolic energy. Ion channels are especially prominent components of the nervous system, since "transmitter-activated" channels mediate conduction across nerve synapses. Ion channels are also key components in the cellular response to toxins and venoms, as well as biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth muscle contraction, T-cell activation and hormone release.

Enzyme-linked receptors are usually single-pass transmembrane receptors. This group includes the highly studied receptor tyrosine kinases (RTKs), which bind to polypeptide growth factors that control cell proliferation and differentiation. Also included are receptor serine/threonine kinases, receptor-like tyrosine phosphatases, and receptor guanylyl cyclases that catalyze the production of cyclic GMP in the cytosol.

G-protein-coupled receptors (GPCRs), also known as 7 transmembrane (7-TM) receptors, are structurally and functionally related proteins characterized by seven membrane-spanning a helices. GPCRs are involved in numerous signaling pathways, including sensory perception (sight, smell, taste, pain). GPCRs are also activated by many neurotransmitters, neuropeptides, and peptide hormones.

Our portfolio of cell surface receptor products includes antibodies, assay kits, cell lines for GPCRs and ion channels, and purified soluble receptors.

References:

1.  Overington, J.P., et al., Nat. Rev. Drug Disc. 2006; 5: 993-996.
2.  Sallman, M. et al., BMC Biol. 2009; 7: 50. 

 

Cell Surface Receptor Subcategories

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Catalog#SizeProduct NamePrice
72308 50 μg CD48, Fc Fusion (IgG1), Biotin-Labeled (Human) HiP™
$420
71178 100 µg CD70, His-tag (Human)
$310
79416 50 μg CD73, Avi-His-Tag, Biotin-Labeled (Mouse) HiP™
$420
70206 100 μg CEACAM, Avi-His-Tag
$320
70201 50 μg CEACAM, Avi-His-Tag, Biotin Labeled
$420
60506 2 vials CFTR – HEK 293 Recombinant Cell Line
$7,500
40686 100 μg CRTAM, Fc-Fusion (IgG1), Avi-Tag
$310
40687 50 μg CRTAM, Fc-Fusion (IgG1), Avi-Tag, Biotin-Labeled
$420
72550 100 μg CSF1R, Fc-Fusion, Avi-Tag (Human) HiP™
$310
79343 50 μg CSF1R, Fc-Fusion, Avi-Tag, Biotin-Labeled
$405
71149-1 100 µg CTLA4 (CD152), Fc fusion (Human)
$210
71149

100 µg
1 mg

CTLA4 (CD152), Fc-tag
Starting at:
$210
72120 384 reactions CTLA4:B7-1 TR-FRET Assay Kit
$1,040
72009 96 reactions CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit
$1,040
72024 96 reactions CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit
$1,045
100094 100 µg FCGR2A, Avi-His-Tag
$310
100089 100 µg FCGR2B, Avi-His-Tag
$310
79016 100 µg FCGR3B, Avi-His-Tag
$310
71123 50 µg Frizzled-1, Fc fusion
$315
71124 50 µg Frizzled-10, Fc fusion
$315
71126 50 µg Frizzled-4, Fc fusion
$315
71139 50 µg Frizzled-7, Fc Fusion
$315
71172 100 µg GITR (CD357), Fc fusion (Human) HiP™
$310
71256 50 ug GITR (CD357), Fc Fusion, Biotin-labeled (Human)
$420
72061 96 reactions GITRL:GITR[Biotinylated] Inhibitor Screening Assay Kit
$1,040

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