CDY1, His-tag Recombinant
Catalog #
55015
$460
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Description
Human chromodomain protein Y-linked 1 (CDY1), also known as CDY and testis-specific chromodomain protein Y 1, GenBank Accession No. NM_170723, a.a. 2-90, with N-terminal His-tag, MW=11.7 kDa, expressed in an E. coli cell expression system.
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Synonyms
chromodomain protein Y-linked 1, CDY1, CDY, testis-specific chromodomain protein Y1
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 300 mM imidazole, 0.04% Tween20, 20% glycerol.
MW
11.7 kDa
Amino Acids
2–90
Genbank #
NM_170723
UniProt #
Q9Y6F8
Background
Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. CDY1 contains a chromodomain and a histone acetyltransferase catalytic domain. CDY1 has histone acetyltransferase activity, with a preference for histone H4. This protein is localized to
the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to
facilitate the transition in which protamines replace histones as the major DNA-packaging protein.
References
1. Fischle, W., et al., J Biol Chem. 2008
Jul 11;283(28):19626-35.
2. Kleiman, S.E., et al., Fertil Steril. 2011
Jun;95(7):2297-302.
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