CD73, Avi-His-Tag (Mouse)

Catalog #: 72523
Size: 100 μg
Species: Mouse
Host Species: HEK293
MW: 61 kDa
Tag(s): Avi-His-Tag
a.a: 29-549

CD39 contributes to immune regulation through the hydrolysis of ATP to AMP in the rate limiting step of extracellular adenosine production. CD39 is expressed on the surface of multiple cells of the immune system including T-cells, Natural killer cells, B-cells, dendritic cells and macrophages. In addition, high levels of CD39 expression have been associated with the tumor microenvironment (TME). Research aimed at reducing immunosuppression by CD39 activity has resulted in the study of a small molecule inhibitor, POM1, and multiple anti-CD39 antibodies selected for blocking enzymatic activity or decreasing CD39 expression. 

CD73/CD39 Immunotherapy

Mouse CD73, also known as 5'-nucleotidase and Ecto-5'-nucleotidase, GenBank Accession No. NM_011851, a.a. 29-549 with C-terminal Avi-His-tag, expressed in a HEK293 cell expression system. MW = 61 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
NT5E,PPARG, ADIPOQ, 5'-Nucleotidase Ecto, Peroxisome Proliferator Activated Receptor Gamma, Adiponectin, C1Q And Collagen Domain Containing, ENTPD1, Ecto-5'-nucleotidase
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Aqueous buffer solution
Storage / Stability:
At least 6 months at -80° C
Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
1. Deaglio, S. et al., J. Exp. Med. 2007; 204(6): 1257-1265. 2. Thompson, L.F., et al., J. Exp. Med. 2004; 200(11): 1395-1405.
The aggregation state of this product has been confirmed to be <10%
Avoid freeze/thaw cycles. Storing diluted protein is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
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