CD73, Avi-His-Tag (Mouse)

Catalog #: 72523
Size: 100 μg
$315
Species: Mouse
Host Species: HEK293
MW: 61 kDa
Tag(s): Avi-His-Tag
a.a: 29-549
Background:

CD39 contributes to immune regulation through the hydrolysis of ATP to AMP in the rate limiting step of extracellular adenosine production. CD39 is expressed on the surface of multiple cells of the immune system including T-cells, Natural killer cells, B-cells, dendritic cells and macrophages. In addition, high levels of CD39 expression have been associated with the tumor microenvironment (TME). Research aimed at reducing immunosuppression by CD39 activity has resulted in the study of a small molecule inhibitor, POM1, and multiple anti-CD39 antibodies selected for blocking enzymatic activity or decreasing CD39 expression. 

CD73/CD39 Immunotherapy

Description:
Mouse CD73, also known as 5'-nucleotidase and Ecto-5'-nucleotidase, GenBank Accession No. NM_011851, a.a. 29-549 with C-terminal Avi-His-tag, expressed in a HEK293 cell expression system. MW = 61 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
UniProt
Q61503
Synonym(s):
NT5E,PPARG, ADIPOQ, 5'-Nucleotidase Ecto, Peroxisome Proliferator Activated Receptor Gamma, Adiponectin, C1Q And Collagen Domain Containing, ENTPD1, Ecto-5'-nucleotidase
Formulation:
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Format:
Aqueous buffer solution
Storage / Stability:
At least 6 months at -80° C
Application(s):
Useful for studying enzyme kinetics, substrate specificity, and screening inhibitors.
Reference(s):
1. Deaglio, S. et al., J. Exp. Med. 2007; 204(6): 1257-1265. 2. Thompson, L.F., et al., J. Exp. Med. 2004; 200(11): 1395-1405.
Notes:
The aggregation state of this product has been confirmed to be <10%
Warning(s):
Avoid freeze/thaw cycles. Storing diluted protein is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Scientific Category:
Immunotherapy
Product Type:
Protein
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Product Datasheets

72523.pdf