CD39, His-Tag (Human)

Catalog #: 71284
Size: 50 µg
$315
Species: Human
Host Species: Expi293
MW: 51 kDa
Genbank #: NM_001776
Tag(s): C-terminal His-tag
a.a: 38-478
Background:

CD39 contributes to immune regulation through the hydrolysis of ATP to AMP in the rate limiting step of extracellular adenosine production. CD39 is expressed on the surface of multiple cells of the immune system including T-cells, Natural killer cells, B-cells, dendritic cells and macrophages. In addition, high levels of CD39 expression have been associated with the tumor microenvironment (TME). Research aimed at reducing immunosuppression by CD39 activity has resulted in the study of a small molecule inhibitor, POM1, and multiple anti-CD39 antibodies selected for blocking enzymatic activity or decreasing CD39 expression. 

Description:
Human CD39, also known as Cluster of Differentiation 39, GenBank Accession number NM_001776, a.a. 38-478 with C-terminal His-tag. MW = 51 kDa, expressed in an Expi293 expression system. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Specific Activity:
≥3000 pmol/min/μg
Assay Conditions:

Done under kit conditions BPS #79278

Formulation:
40mM Tris-HCl, pH8, 110mM NaCl, 2.2mM KCl, and 20% glycerol
Storage / Stability:
At least 6 months at –80°C. Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary use carrier protein (BSA 0.1 – 0.5%).
Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):
1. Deaglio, S. et al., Journal of Environmental Medicine. 2007 Jun 204(6): 1257-1265.

2. Borsellino, G. et al., Blood. 2007 Aug; 110(4):1225-1232.

Scientific Category:
Immunotherapy
Product Type:
Recombinant Protein
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Product Datasheets

71284_lot_180410.pdf