CD123 (IL3Ra) - CHO Recombinant Cell Line (High, Medium, or Low Expression)

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Catalog #
79640
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Description

Stable, recombinant clonal CHO cell line constitutively expressing full length human CD123 protein (Genbank #NM_002183.2). Surface expression of CD123 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD123 expression to mimic different stages of cancer target cells with various CD123 expression levels.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Product Info
Storage and Usage
Citations
Host Cell Line
Chinese Hamster Ovary
Supplied As
Each vial contains ~ 2 x 10^6 cells in 1 ml of FBS + 10% DMSO.
UniProt #
P26951
Mycoplasma Testing
This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of mycoplasma contamination.
Background
CD123, also known as interleukin 3 receptor alpha (IL3Ra), is a transmembrane protein normally expressed on basophils and plasmacytoid dendritic cells and overexpressed on multiple blood cancers and leukemic hematopoietic stem cells. It normally plays a role in cell proliferation. CAR-Ts and other therapies targeting CD123 are currently being evaluated in clinical trials. CD123 may be especially valuable in treating B cell acute lymphoblastic leukemia patients who have relapsed after CD19 CAR-T treatment.