CD112, His-Tag, Biotin-Labeled (Human) HiP™ Recombinant
Human secreted CD112, encompassing amino acids 32-360. This construct has a C-terminal His-tag followed by an Avi-Tag™. This protein was enzymatically biotinylated using Avi-tag™ technology and was affinity purified. HiP™ indicates a high purity protein with ≥90% purity as measured by gel filtration.
≥90%
This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation confirmed to be ≥90%.
For more information on enzymatic biotinylation, please see our Tech Note.
CD112 (Poliovirus receptor-related 2, PVRL2, or nectin-2), is widely expressed on antigen presenting cells and tumor cells and is the high affinity ligand of CD112R (Poliovirus receptor related immunoglobulin domain containing, PVRIG). CD112R is found in NK and T cells, and in T cells it is found particularly in CD8+ T cells. High levels of this protein are found in NK, CD8+ and CD4+ T cells of patients with kidney, ovary, lung, prostrate and endometrium cancer and acute myeloid leukemia (AML). CD112 has also been linked to tumor angiogenesis, growth and metastasis. It has a wider pattern of expression, being also present in endothelial cells, neurons and fibroblasts. CD112-CD112R interaction is a positive immune checkpoint that enhances human T cell response and has emerged as an attractive therapeutic target for oncology. TIGIT (T cell immunoreceptor with Ig and ITIM domains) and CD226 (also called DNAM-1, DNAX Accessory Molecule-1) also bind CD112. The development of inhibitors able to prevent the interaction between CD112R-CD112 alone or in combination with blockage of TIGIT-CD155/CD112 interaction may prove beneficial in cancer therapy.
1. Bottino, C., et al., J. Exp. Med. 2003; 198(4): 557-567.
2. Pende, D., et al., Blood. 2005; 105(5): 2066-2073.
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