CBX2, GST-tag Recombinant

Catalog #

55011

$460 *

Size: 100 µg

Qty

Bulk/Custom

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Description

Human chromobox homolog 2 (CBX2), also known as SRXY5 and cell division cycle associated 6 (CDCA6), GenBank Accession No. NM_005189, a.a. 2-90, with N-terminal GST-tag, MW=37.3 kDa, expressed in an E. coli cell expression system.

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Synonyms

chromobox homolog 2,CBX2, SRXY5, cell division cycle associated 6, CDCA6, CBX-2

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥79%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol.

37.3 kDa

Amino Acids

2–90

Genbank #

NM_005189

UniProt #

Q14781

Tag(s)

N-terminal GST-tag

Background

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys119, rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression.

References

1. Völkel, P., et al., Epigenetics. 2012
May ;7(5) :482-91.
2. Morey, L., et al., Cell Stem Cell. 2012
Jan 6 ;10(1) :47-62.

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Datasheets/Protocols

55011_Lot121109.pdf

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