CBX1, GST-tag Recombinant

Catalog #
55009
$460 *
Size: 100 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

Human chromobox homolog 1 (CBX1), also known as p25beta, M31, HP1-beta, and MOD1, GenBank Accession No. NM_006807, a.a. 2-185(end), with N-terminal GST-tag, MW=48.1 kDa, expressed in an E. coli cell expression system.

Synonyms
cbx, cbx1, Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX-1
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity

≥78%

Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, and 20% glycerol.
MW
48.1 kDa
Amino Acids
2–185(end)
Genbank #
NM_006807
UniProt #
P83916
Tag(s)
N-terminal GST-tag
Background
Component of heterochromatin. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Recognizes and binds histone H3 tails methylated at Lys9, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
References

1. Furuta, K., et al., Chromosoma. 1997
Jun;106(1) :11-9.
2. Ekblad, C.M., et al., EMBO Rep. 2005
Jul;6(7) :675-80.