Caspase8, His-tag Recombinant

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Catalog #
80114
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Description

Human Caspase 8 (CASP8), GenBank Accession No. NM_001228), a.a. 200 - 496 (end), with C-terminal His-tag, MW=34.5 kDa, expressed in an E. coli cell expression system. Procaspase-8 is autocleaved between the prodomain and large protease subunit (p18). The cleavage product, p30, contains both the large (p18) and small (p10 [His-tag]) protease subunits. p30 is further processed to the p18 and p10 subunits, which dimerize to form active enzyme.

Synonyms
Caspase-8, CASP8, Caspase 8, FLICE, MACH, Mch5, Caspase
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity

≥90%

Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, 3 mM DTT and 20% glycerol.
MW
see Description
Amino Acids
200 – 496 (end)
Specific Activity
≥ 1145 pmol/min/µg
Genbank #
NM_001228
UniProt #
Q14790
Tag(s)
C-terminal His-tag
Background
Caspase-8 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Caspase-8 has been associated with chronic inflammation and neurodegenerative disorders including Alzheimer’s, Huntington’s, and Parkinson’s.
References
1. MacPherson, G., et al., J. Natl.Cancer Inst. 2004 Dec 15;96(24):1866-9.
2. Sun, T., et al., Nat Genet. 2007 May;39(5):605-13.
3. Hoffman, J.C., et al. Mol. Cell. Biol. 2009 Aug; 29(16): 4431-4440.