Carbonic Anhydrase 9 (CA9), His-tag Recombinant
Catalog #
71101
$505
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Description
Human carbonic anhydrase IX (CA IX), also known as CA9, (GenBank Accession No. NM_001216), a.a. 59-414 with C-terminal His-tag, MW = 39.7 kDa, expressed in a baculovirus infected Sf9 cell expression system.
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Synonyms
Carbonic Anhydrase IX, PMW, RCC-Associated Antigen G250, CAIX, Carbonic Anhydrase 9, Carbonate Dehydratase, CA9
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥65%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 266 mM imidazole and 20% glycerol
MW
39.7 kDa
Amino Acids
59–414
Genbank #
NM_001216
UniProt #
Q16790
Background
CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. Expression of the membrane-bound carbonic anhydrase, CA IX, has been reported in hypoxic tumors where its activity is linked to promoting survival of tumor cells and aiding cancer progression. This is thought to occur through the carbonic anhyrase-mediated production of bicarbonate ions, which neutralizes the abnormally acidic pH of the extracellular environment induced during hypoxia. Furthermore, as CA IX is a hypoxia- and HIF-1-inducible enzyme, its expression can be used as a biomarker for hypoxic tumors.
References
1. Hilvo, M., et al., J Biol Chem. 2008 Oct 10;283(41):27799-809.
2. Chadwick, A.L., et al., Cell Cycle. 2013 Jul 30;12(16):2534.
2. Chadwick, A.L., et al., Cell Cycle. 2013 Jul 30;12(16):2534.
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