CAMK2γ, GST-tag Recombinant

Catalog #

40042

$410 *

Size: 10 µg

Qty

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Description

Recombinant human CAMK2γ (C-terminal truncation), with N-terminal GST-tag, expressed by baculovirus in Sf9 cells

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Synonyms

CAMKG, CAMK, CAMK-II, MGC26678, CAMK-2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

60 kDa

Amino Acids

1–527

Genbank #

NM_172169

UniProt #

Q13555

Tag(s)

N-terminal GST-tag

Background

CAMK2γ is a member of the CAMKII family which are ubiquitous serine/threonine protein kinases that have been implicated in diverse effects of hormones and neurotransmitters. CAMK2γ has six alternatively spliced variants that encode six different isoforms. Some of these variants have been identified in human tumors (1). Transgenic mice expressing a partially calcium-independent mutant form of CAMKG showed 1.5- to 2-fold increase in the thymus of these mice, at least in part due to an increase in the life span of double-positive thymocytes (2). There was an increase in the number of T cells in the secondary lymphoid organs that had acquired an antigen-dependent memory phenotype.

References

1. Tombes, R. M. et al: Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355: 281-292, 1997.
2. Bui, J. D. et al: A role for CaMKII in T cell memory. Cell 100: 457-467, 2000.

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CAMK2γ, GST-tag Recombinant

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