CAMK2δ, GST-tag Recombinant

Catalog #

40043

$410 *

Size: 10 µg

Qty

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Description

Recombinant human CAMK2δ, full length, with N-terminal GST-tag, expressed by baculovirus in Sf9 cells

This product has been cited 1 time.

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Synonyms

CAMKD, MGC44911, CAMK-2

Product Info

Storage and Usage

Citations1

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

77 kDa

Amino Acids

full length

Genbank #

NM_172115

UniProt #

Q13557

Tag(s)

N-terminal GST-tag

Background

CAMK2D is a serine/threonine protein kinase that is a member of the type II multifunctional Ca2+/calmodulin-dependent protein kinase family. CAMK2D is abundantly present in human cardiac and skeletal muscle and its levels are increased in the heart of patients suffering from cardiomyopathy (1). In cardiomyocytes, stimulation of beta-1-adrenergic receptor leads to induction of apoptosis, an effect that is mediated by activation of CAMK2D in a PKA-independent manner. In addition, expression studies have revealed the downregulation of CAMK2D in human tumor cells.

References

1. Hoch, B. Et al: Identification and expression of delta-isoforms of the multifunctional Ca(2+)/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ. Res. 84: 713-721, 1999.
2. Zhu, W.-Z. Et al: Linkage of beta-1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca(2+)/calmodulin kinase II. J. Clin. Invest. 111: 617-625, 2003.

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CAMK2δ, GST-tag Recombinant

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