CAMK1, Mouse, GST-tag Recombinant

Catalog #

40030

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant mouse CAMK1, full length, with N-terminal GST-tag, expressed in E. coli cells

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Synonyms

CaMKIalpha, AI505105; D6Ertd263e, CAMK-1

Product Info

Storage and Usage

Citations

Species

Mouse

Host Species/Expression System

E. coli

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

70 kDa

Amino Acids

full length

Genbank #

NM_133926

Tag(s)

N-terminal GST-tag

Background

CAMK1 is a serine/threonine protein kinase that is a member of the multifunctional calcium/calmodulin-dependent protein kinase family. CAMK1 is ubiquitously expressed and phosphorylates a number of proteins including SYN1, SYN2, CREB and CFTR. In addition, Numb family of proteins may also be intracellular targets for CAMK1, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein (1). CAMK1 also plays an important role in the trafficking of HDAC7 between the cytoplasm and the nucleus. CAMK1 phosphorylates HDAC7 on multiple sites that lead to alteration in localization of HDAC7 (2).

References

1. Tokumitsu, H. et al: Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. J Biol Chem. 2005 Oct 21;280(42):35108-18.
2. Gao, C. et al: CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. FEBS Lett. 2006 Sep 18;580(21):5096-104.

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CAMK1, Mouse, GST-tag Recombinant

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