Bromosporine
Catalog #
27612
$195
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Description
Bromosporine is a broad spectrum inhibitor for bromodomains.
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Synonyms
ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate
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Product Data Gallery
Product Info
Storage and Usage
Citations
Formula
C17H20N6O4S
MW
404.4 Da
Solubility
Soluble in DMSO (100 mM) and ethanol (25 mM)
Biological Activity
Bromosporine exhibits IC50 values of 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively.
Background
Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
References
Gallenkamp et al. (2014). Chem Med Chem 9:438.