Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

Items 101 to 125 of 151 total

per page
Page:
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7

Catalog#SizeProduct NamePrice
27336 1 mg I-CBP112 (Hydrochloride)
$45
27636-1 5 mg OTX-015
$295
27636-2 10 mg OTX-015
$435
27636-3 25 mg OTX-015
$610
31118 100 µg P300 (1046-1163), His-tag
$305
31122 100 µg PB1 (BD4), His-tag
$305
31133 100 µg PB1 (BD6), His-tag
$305
31120 100 µg PCAF (KAT2B), His-tag
$305
27332 25 mg PFI-1
$330
31142 100 µg PHIP (BD1), GST-tag
$305
31140 100 µg PHIP (BD1), His-tag
$305
27403 1 mg RediSolution™ (+)-JQ1
$85
27111 5 mg RVX-208
$230
27650-1 10 mg SGC-CBP30
$220
27650-2 50 mg SGC-CBP30
$575
32610 384 reactions SMARCA2 Inhibitor Screening Assay Kit
$510
40342 384 reactions SMARCA2 TR-FRET Assay Kit
$510
31141 100 µg SMARCA2, GST-tag
$305
31111 100 µg SMARCA2, His-tag
$305
31129 50 μg SMARCA2, His-Tag, Biotin-Labeled
$305
31132 100 µg SMARCA4 (BRG1), GST-tag
$305
31102 100 µg SMARCA4 (BRG1), His-tag
$305
32609 384 reactions SMARCA4/BRG1 Inhibitor Screening Assay Kit
$510
40341 384 reactions SMARCA4/BRG1 TR-FRET Assay Kit
$510
31123 100 µg TAF1 (BD1), His-tag
$305

Items 101 to 125 of 151 total

per page
Page:
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7