Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
31138 100 µg CECR2, GST-tag
$295
31046 100 µg CECR2, His-tag
$295
27333 25 mg CHS-828
$335
31128 100 µg CREBBP (KAT3A), GST-tag
$295
31119 100 µg CREBBP (KAT3A), His-tag
$295
32619 384 Reactions CREBBP TR-FRET Assay Kit
$495
31134 100 µg FALZ (BPTF), GST-tag

Regular Price: $295

Special Price $177

31131 100 µg FALZ (BPTF), His-tag

Regular Price: $295

Special Price $177

31114 100 µg GCN5 (727-837), His-tag
$295
27630-1 5 mg I-BET-762
$445
27630-2 10 mg I-BET-762
$715
27629-1 5 mg I-BET151 (GSK1210151A)
$185
27629-2 10 mg I-BET151 (GSK1210151A)
$210
27629-3 50 mg I-BET151 (GSK1210151A)
$425
27336 1 mg I-CBP112 (Hydrochloride)
$40
27636-1 5 mg OTX-015
$285
27636-2 10 mg OTX-015
$420
27636-3 25 mg OTX-015
$590
31118 100 µg P300 (1046-1163), His-tag
$295
31122 100 µg PB1 (BD4), His-tag

Regular Price: $295

Special Price $177

31133 100 µg PB1 (BD6), His-tag
$295
31120 100 µg PCAF (KAT2B), His-tag
$295
27332 25 mg PFI-1
$320
31142 100 µg PHIP (BD1), GST-tag
$295
31140 100 µg PHIP (BD1), His-tag

Regular Price: $295

Special Price $177

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