Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

Items 76 to 100 of 151 total

per page
Page:
  1. 2
  2. 3
  3. 4
  4. 5
  5. 6

Catalog#SizeProduct NamePrice
31040 100 µg BRD4 (BD1), GST-tag
$295
31042 100 µg BRD4 (BD1), His-tag
$295
31047 100 µg BRD4 (BD1+BD2)
$295
31044 100 µg BRD4 (BD1+BD2), GST-tag
$295
31045 100 µg BRD4 (BD1+BD2), His-tag
$295
31041 100 µg BRD4 (BD2), GST-tag
$295
31043 100 µg BRD4 (BD2), His-tag
$295
31091 100 µg BRD9, GST-tag
$295
31090 100 µg BRD9, His-tag
$295
31108 100 µg BRDT (BD1), GST-tag
$295
31101 100 µg BRDT (BD1), His-tag
$295
31061 100 µg BRDT (BD1+BD2), GST-tag
$295
31060 100 µg BRDT (BD2), GST-tag
$295
31100 100 µg BRDT (BD2), His-tag
$295
33008 0.5 ml @ 20 µM Bromodomain Ligand 3
$435
33010 0.5 ml @ 20 µM Bromodomain Ligand 4
$435
33005 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 1
$435
33004 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 2
$435
33009 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 3
$435
33011 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 4
$435
27612 1 mg Bromosporine
$160
31112 100 µg BRPF1, His-tag
$295
31130 100 µg BRPF3, GST-tag
$295
31138 100 µg CECR2, GST-tag
$295
31046 100 µg CECR2, His-tag
$295

Items 76 to 100 of 151 total

per page
Page:
  1. 2
  2. 3
  3. 4
  4. 5
  5. 6