Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
33004 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 2
$450
33009 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 3
$450
33011 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 4
$450
27612 1 mg Bromosporine
$165
31112 100 µg BRPF1, His-tag
$305
32608 384 reactions BRPF3 Inhibitor Screening Assay Kit
$1,025
32626 384 reactions BRPF3 TR-FRET Assay Kit
$1,025
31130 100 µg BRPF3, GST-tag
$305
32611 384 reactions CECR2 Inhibitor Screening Assay Kit
$1,025
32622 384 reactions CECR2 TR-FRET Assay Kit
$510
31138 100 µg CECR2, GST-tag
$305
31046 100 µg CECR2, His-tag
$305
27333 25 mg CHS-828
$345
31128 100 µg CREBBP (KAT3A), GST-tag
$305
31119 100 µg CREBBP (KAT3A), His-tag
$305
32607 384 reactions CREBBP Inhibitor Screening Assay Kit
$510
32619 384 Reactions CREBBP TR-FRET Assay Kit
$510
31134 100 µg FALZ (BPTF), GST-tag
$305
31131 100 µg FALZ (BPTF), His-tag
$305
31114 100 µg GCN5 (727-837), His-tag
$305
27630-2 10 mg I-BET-762
$735
27630-1 5 mg I-BET-762
$460
27629-2 10 mg I-BET151 (GSK1210151A)
$215
27629-3 50 mg I-BET151 (GSK1210151A)
$440
27629-1 5 mg I-BET151 (GSK1210151A)
$190

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