Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
31147 100 µg ASH1L, His-tag
$295
31121 100 µg ATAD2A, GST-tag
$295
31109 100 µg ATAD2A, His-tag
$295
31125 100 µg ATAD2B (KIAA1240), GST-tag
$295
31117 100 µg ATAD2B (KIAA1240), His-tag
$295
31136 100 µg BAZ1A, GST-tag
$295
31137 100 µg BAZ1B, GST-tag
$295
31145 100 µg BAZ1B, His-tag
$295
31113 100 µg BAZ2B, His-tag
$295
33000 0.5 ml @ 20 µM BET Bromodomain Ligand
$435
31011 100 µg BRD1, GST-tag
$295
31010 100 µg BRD1, His-tag
$295
31021 100 µg BRD2 (BD1), GST-tag
$295
31022 100 µg BRD2 (BD1), His-tag
$295
31024 100 µg BRD2 (BD1+BD2), GST-tag
$295
31025 100 µg BRD2 (BD1+BD2), His-tag
$295
31023 100 µg BRD2 (BD2), GST-tag
$295
31020 100 µg BRD2 (BD2), His-tag
$295
31032 100 µg BRD3 (BD1), GST-tag
$295
31030 100 µg BRD3 (BD1), His-tag
$295
31035 100 µg BRD3 (BD1+BD2), GST-tag
$295
31034 100 µg BRD3 (BD1+BD2), His-tag
$295
31033 100 µg BRD3 (BD2), GST-tag
$295
31031 100 µg BRD3 (BD2), His-tag
$295
32613 384 reactions BRD4 (BD1) TR-FRET Assay Kit
$495

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