Bromodomain(s)

 

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Our portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of our products, we perform rigorous QC testing of our bromodomain products to ensure that we are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

 

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Catalog#SizeProduct NamePrice
32514 384 reactions BRD4 (BD1) Inhibitor Screening Assay Kit
$510
32613 384 reactions BRD4 (BD1) TR-FRET Assay Kit
$510
31040 100 µg BRD4 (BD1), GST-tag
$305
31042 100 µg BRD4 (BD1), His-tag
$305
31047 100 µg BRD4 (BD1+BD2)
$305
32612 384 reactions BRD4 (BD1+BD2) TR-FRET Assay Kit
$510
31044 100 µg BRD4 (BD1+BD2), GST-tag
$305
31045 100 µg BRD4 (BD1+BD2), His-tag
$305
32524 384 reactions BRD4 (BD2) Inhibitor Screening Assay Kit
$510
32617 384 reactions BRD4 (BD2) TR-FRET Assay Kit
$510
31041 100 µg BRD4 (BD2), GST-tag
$305
31043 100 µg BRD4 (BD2), His-tag
$305
32519 384 reactions BRD9 (BD1) Inhibitor Screening Assay Kit
$510
32621 384 reactions BRD9 TR-FRET Assay Kit
$510
31091 100 µg BRD9, GST-tag
$305
31090 100 µg BRD9, His-tag
$305
31108 100 µg BRDT (BD1), GST-tag
$305
31101 100 µg BRDT (BD1), His-tag
$305
32616 384 reactions BRDT (BD1+BD2) TR-FRET Assay Kit
$510
31061 100 µg BRDT (BD1+BD2), GST-tag
$305
31060 100 µg BRDT (BD2), GST-tag
$305
31100 100 µg BRDT (BD2), His-tag
$305
33008 0.5 ml @ 20 µM Bromodomain Ligand 3
$450
33010 0.5 ml @ 20 µM Bromodomain Ligand 4
$450
33005 0.5 ml @ 20 µM Bromodomain Non-Acetylated Ligand 1
$450

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