BIBR 1532

Catalog #: 27740-2
Size: 100 mg
$170
MW: 331.4 Da
CAS Registry #: 321674-73-1
Formula: C21H17NO3
Target: Telomerase
Background:
It has been reported that BIBR 1532 inhibited the reverse transcriptase of telomerase, hTERT, and shortened the length of the telomerase to suppress human cancer cell proliferation. In pre-B acute lymphoblastic leukemia cells, BIBR1532 suppressed c-Myc and hTERT expression in a concentration-dependent manner to inhibit telomerase activity, and high doses of BIBR1532 could induce apoptosis by elevating p73, Bax/Bcl-2 and caspase-3 activation. In NB4 leukemic cells, combined treatments with BIBR 1532 and arsenic trioxide suppressed cell proliferative capacity and inhibited telomerase activity probably via transcriptional suppression of c-Myc and hTERT.
Description:
BIBR 1532 is a novel, specific telomerase inhibitor with IC50 = 93 nM.
Synonym(s):
2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid
Solubility:
Soluble in DMSO
Storage / Stability:

Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Reference(s):
1. Damm, K., et al. EMBO J. 2001, 20, 6958?6968.
2. Bashash D., et al. Leuk Lymphoma. 2013 Mar;54[4]:561-8.
3. Bashash D., et al. Anticancer Agents Med Chem. 2013 Sep;13(7):1115-25.
Scientific Category:
Telomerase
Product Type:
Inhibitor
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