Human beta Defensin-4 Recombinant

Catalog #
90109-A
$130 *
Size: 5 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

Recombinant beta Defensin-4 is a disulfide-linked monomer protein consisting of 51 amino acid residues, and migrates as an approximately 6 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human beta Defensin-e mature chain was expressed in E. coli.

Synonyms
BD4, beta defensin 4, DEFB104A
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered 100 mM NaCl, 20 mM phosphate buffer, pH 7.4.
MW
6 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
23–72
Biological Activity
The ED50 was determined by its ability to chemoattract immature human dendritic cells using a concentration range of 1-50 ng/ml.
Genbank #
Q8WTQ1
UniProt #
Q8WTQ1
Background
Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides. It is thought that defensins function in the eradication of pathogens from the host system by inserting themselves into the bacterial membrane under the influence of membrane potential, forming channels which lead to leakage of cytoplasmic molecules and cell death.
References
Vankeerberghen, A., et al. Genomics. 2005 May,85(5):574-81.