BCL-2, His-Tag Recombinant

Catalog #
50272
$450 *
Size: 100 µg
Qty
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Description

Recombinant human BCL-2 (apoptosis regulator Bcl-2), encompassing amino acids 1-211. This construct contains a C- terminal His-tag (10xHis). The recombinant protein was affinity purified.

Synonyms
Bcl, Bcl2, B cell lymphoma 2
Product Info
Storage and Usage
Citations
Species
Human
Construct
BCL-2 (1-211-His)
Host Species/Expression System
E. coli
Purity

≥90%

Format
Aqueous buffer solution
Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and variable imidazole

MW
25 kDa
Amino Acids
1–211
Genbank #
NM_000633
UniProt #
P10415
Tag(s)
C-terminal His-tag
Background
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
References
1. Labi V. et al., Cell Death Differ. 2008 Jun;15(6):977-87.
2. Rong Y.P. et al., Mol Cell. 2008 Jul 25;31(2):255-65.