BAY-11-7082
Catalog #
27229
$155
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Description
BAY-11-7082 is a selective and irreversible inhibitor of NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. It also inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells.
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Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Format
A crystalline solid.
Formula
C10H9NO2S
MW
207.3 Da
Solubility
Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in ethanol is
~ 0.20 mg/ml, and in DMSO and DMF is 25 mg/ml.
Biological Activity
BAY-11-7082 inhibits TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin with IC50 values of 5-10 µM.
CAS Registry #
19542-67-7
References
1. Pahl, H., et al., Oncogene. 1999;18:6853-6866.
2. Gilmore, TD, et al., Oncogene. 1999;18:6842-6844.
3. Karin, M., et al., J. Biol. Chem. 1999;274(39):27339-27342.
2. Gilmore, TD, et al., Oncogene. 1999;18:6842-6844.
3. Karin, M., et al., J. Biol. Chem. 1999;274(39):27339-27342.
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