b-AP15 (NSC-687852)

Catalog #
27701-1
$180 *
Size: 5 mg
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Description

Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.

Synonyms
b–AP15, NSC–687852, 3,5–Bis[(4–nitrophenyl)methylene]–1?–(1–oxo–2–propene–1–yl)–4–piperidone
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC.
Format
Pale yellow powder
Formula
C22H17N3O6
MW
419.4 Da
Solubility
Soluble in DMSO (35 mg/ml)
CAS Registry #
1009817-63-3