b-AP15 (NSC-687852)

Catalog #: 27701-2
Size: 25 mg
$250
MW: 419.4 Da
CAS Registry #: 1009817-63-3
Formula: C22H17N3O6
Description:
Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.
Synonym(s):
b–AP15, NSC–687852, 3,5–Bis[(4–nitrophenyl)methylene]–1?–(1–oxo–2–propene–1–yl)–4–piperidone
Purity:
≥98% by HPLC.
Solubility:
Soluble in DMSO (35 mg/ml)
Format:
Pale yellow powder
Application(s):
Suitable for validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target, as well as cell-based and in vitro characterization UCH-L5 or USP14 activity.
Warning(s):
Protect from moisture.
Scientific Category:
Ubiquitin Enzymes
Product Type:
Inhibitors/Activators
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