AZD2281 (Olaparib)

Catalog #: 27003
Size: 25 mg
$170
MW: 434.5 Da
CAS Registry #: 763113-22-0
Formula: C24H23FN4O3
Description:
AZD2281, also known as Olaparib, is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor and an anti-cancer drug being tested in patients with mutations in the genes BRCA1 or BRCA2.
Synonym(s):
AZD-2281] [KU-59436
Purity:

≥95% by HPLC

Biological Activity:
Olaparib (AZD2281) is a potent PARP inhibitor with IC50 of 1.1 nM for PARP1 using the BPS Bioscience PARP1 Assay Kit (Cat. # 80551). It inhibits PARP2 with IC50 = 0.9 nM for using the BPS Bioscience PARP2 Assay Kit (Cat. # 80552).
Solubility:
Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 ┬ÁM buffers, serum, or other additives may increase or decrease the aqueous solubility.
Format:
White to off-white crystalline solid; granular or powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. De Murcia, J., et al., Proc. Natl. Acad. Sci. USA 94: 7303 – 7307 (1997)
2. Bryant, H.E., et al., Nature 434: 913 – 915 (2005)
3. Farmer, H., et al., Nature 434: 917 – 921 (2005)
Scientific Category:
PARP
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.

Quality Assurance

Product Datasheets

27003_Lot111118.pdf