AZD2281 (Olaparib)

Catalog #
27003
$200 *
Size: 250 mg
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Description

AZD2281, also known as Olaparib, is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor and an anti-cancer drug being tested in patients with mutations in the genes BRCA1 or BRCA2.

This product has been cited 4 times.

Synonyms
AZD-2281] [KU-59436
Product Info
Storage and Usage
Citations4
Purity

≥99% by HPLC

Format
White to off-white crystalline solid; granular or powder.
Formula
C24H23FN4O3
MW
434.46 Da
Solubility
Soluble in DMSO at 33 mg/ml; soluble in ethanol at 1.7 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM buffers, serum, or other additives may increase or decrease the aqueous solubility.
Biological Activity
Olaparib (AZD2281) is a potent PARP inhibitor with IC50 of 1.1 nM for PARP1 using the BPS Bioscience PARP1 Assay Kit (Cat. # 80551). It inhibits PARP2 with IC50 = 0.9 nM for using the BPS Bioscience PARP2 Assay Kit (Cat. # 80552).
CAS Registry #
763113-22-0
References

1. De Murcia, J., et al., Proc. Natl. Acad. Sci. USA 94: 7303 – 7307 (1997)
2. Bryant, H.E., et al., Nature 434: 913 – 915 (2005)
3. Farmer, H., et al., Nature 434: 917 – 921 (2005)