Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

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Catalog#SizeProduct NamePrice
27660-2 50 mg Tenovin-1
$230
27660-3 100 mg Tenovin-1
$400
27661-3 10 mg Tenovin-6
$850
27661-1 1 mg Tenovin-6
$190
27661-2 5 mg Tenovin-6
$570
27320 100 mg Trimidox
$605
27319 50 mg Trimidox
$405
27775-1 10 mg TW-37
$205
27775-2 50 mg TW-37
$525
27775-3 25 mg TW-37
$335
27779-3 50 mg VX-765
$325
27779-1 100 mg VX-765
$505
27779-2 10 mg VX-765
$185
80016 50 μg WDR5, His-Tag, Biotin-Labeled
$455
75002 50 µg XIAP (Bir2,Bir3), His-tag
$310
75001 50 µg XIAP (Bir3), His-tag
$310
80401 20 µg XIAP, FLAG-tag
$385
27314 5 mg Z-DEVD-FMK
$210
27666-3 25 mg Z-DQMD-FMK
$485
27666-2 10 mg Z-DQMD-FMK
$315
27667-3 10 mg Z-FA-FMK
$425
27667-1 5 mg Z-FA-FMK
$280
27667-2 25 mg Z-FA-FMK
$485
27313 5 mg Z-VAD(OMe)-FMK
$450
27668-2 10 mg Z-VDVAD-FMK
$550

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