Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

Items 76 to 100 of 102 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Catalog#SizeProduct NamePrice
27661-1 1 mg Tenovin-6
$195
27319 50 mg Trimidox
$415
27320 100 mg Trimidox
$625
27775-1 10 mg TW-37
$210
27775-2 50 mg TW-37
$540
27775-3 25 mg TW-37
$345
27779-3 50 mg VX-765
$335
27779-1 100 mg VX-765
$520
27779-2 10 mg VX-765
$190
80016 50 μg WDR5, His-Tag, Biotin-Labeled
$470
75002 50 µg XIAP (Bir2,Bir3), His-tag
$320
75001 50 µg XIAP (Bir3), His-tag
$320
80401 20 µg XIAP, FLAG-tag
$395
27314 5 mg Z-DEVD-FMK
$215
27666-2 10 mg Z-DQMD-FMK
$325
27666-3 25 mg Z-DQMD-FMK
$500
27667-2 25 mg Z-FA-FMK
$500
27667-3 10 mg Z-FA-FMK
$440
27667-1 5 mg Z-FA-FMK
$290
27313 5 mg Z-VAD(OMe)-FMK
$465
27668-1 5 mg Z-VDVAD-FMK
$380
27668-2 10 mg Z-VDVAD-FMK
$565
27669-2 10 mg Z-VEID-FMK
$565
27669-1 5 mg Z-VEID-FMK
$380
27672-2 10 mg Z-WEHD-FMK
$325

Items 76 to 100 of 102 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5