Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

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Catalog#SizeProduct NamePrice
27746 1 g Cycloheximide
$185
27748-2 10 mg Elesclomol (STA-4783)
$290
27748-1 5 mg Elesclomol (STA-4783)
$180
27322 100 mg Embelin
$455
79506 384 reactions MCL-1 TR-FRET Assay Kit
$790
40742 100 µg MCL1, His-Tag
$320
27763 10 mg Mitomycin C
$145
80117 5 µg NLRP3 (NALP3), His-FLAG-tags (Sf9-derived)
$470
27318 500 mg Oxyresveratrol
$580
27316 50 mg PCI 34051
$505
27317 100 mg PCI 34051
$705
27640-1 5 mg Q-VD(OMe)-OPh
$380
27640-2 10 mg Q-VD(OMe)-OPh
$565
100069 100 µg SARM1, FLAG-Tag
$415
27651-3 50 mg SGI-1776 free base
$510
27651-1 5 mg SGI-1776 free base
$155
27651-2 10 mg SGI-1776 free base
$235
75003 20 µg STAT3, GST-tag
$320
27656-1 100 mg Streptozocin (U-9889)
$130
27656-2 500 mg Streptozocin (U-9889)
$215
27660-3 100 mg Tenovin-1
$410
27660-1 25 mg Tenovin-1
$155
27660-2 50 mg Tenovin-1
$235
27661-2 5 mg Tenovin-6
$585
27661-3 10 mg Tenovin-6
$875

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