Apoptosis

 

Apoptosis is the process of programmed cell death. During apoptosis, a cell initiates intracellular signaling in response to a strong stress or other cue. Death via apoptosis is characterized by many phenotypic changes in a cell, including cell shrinking, nuclear and chromosomal fragmentation, and PARP cleavage. Apoptosis is critical for proper embryonic development, immune system function, and hormone-dependent atrophy. Many of the most widely used cancer therapeutics activate apoptotic machinery to kill cancer cells. Alternately, inhibitors of apoptosis may also have therapeutic value in preventing unregulated apoptosis in HIV or neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s).

There are two known apoptosis signal transduction pathways – the mitochondrial, or intrinsic pathway, and the death receptor, or extrinsic pathway. Apoptosis via the intrinsic pathway occurs when apoptotic stimuli trigger release of mitochondrial intermembrane proteins and SMAC in to the cytosol. These proteins ultimately coordinate to activate caspases which facilitate the process of programmed cell death. Conversely, apoptosis via the extrinsic pathway, as the name implies, relies on signals from outside of the cell. Specifically, death receptors on the surface of cells engage with their cognate ligands and this interaction leads to activation of signal transduction pathways that can activate caspases directly or indirectly through the Bcl-2 family of proteins.

BPS has a number of apoptosis proteins, assay kits, and inhibitors & activators to suit your research goals. These assay kits are easy to use and excellent for high throughput screening (HTS) applications.

References:

1.  Ouyang, L. et al., Cell Proliferat. 2012; 45(6): 487-498.

 

Apoptosis Subcategories

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Catalog#SizeProduct NamePrice
27611-2 10 mg Boc-D-FMK
$285
27611-3 25 mg Boc-D-FMK
$595
27611-1 5 mg Boc-D-FMK
$210
80700 96 reactions Caspase-3 Homogeneous Assay Kit
$275
27741-2 10 mg Caspase-3/7 Inhibitor I
$440
27741-3 25 mg Caspase-3/7 Inhibitor I
$640
27741-1 5 mg Caspase-3/7 Inhibitor I
$305
80703 96 reactions Caspase-6 Homogeneous Assay Kit
$355
80701 96 reactions Caspase-7 Homogeneous Assay Kit
$355
80704 96 reactions Caspase-8 Homogeneous Assay Kit
$355
80500 50 µg Caspase3, His-tag
$425
80113 50 µg Caspase6, His-tag
$435
70000 50 µg Caspase7, His-tag
$435
80114 50 µg Caspase8, His-tag
$435
80115 50 µg Caspase9, His-tag
$355
27321 10 mg CAY10625
$530
27744 5 mg Cisplatin
$160
27745-2 10 mg Costunolide
$150
27745-1 5 mg Costunolide
$125
27746 1 g Cycloheximide
$180
27748-2 10 mg Elesclomol (STA-4783)
$280
27748-1 5 mg Elesclomol (STA-4783)
$175
27322 100 mg Embelin
$440
79506 384 reactions MCL-1 TR-FRET Assay Kit
$765
40742 100 µg MCL1, His-Tag
$310

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