Anti–LSD1 polyclonal antibody

Catalog #
25302
$415 *
Size: 50 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

Polyclonal antibody raised in rabbit against human LSD1 (Lysine–specific demethylase 1), using a KLH–conjugated synthetic peptide from the inner part of the protein

Synonyms
BHC110, AOF2, EC1, KDM1a, LSD
Product Info
Storage and Usage
Citations
Clonality
polyclonal
Host Species/Expression System
Rabbit
Purification
Affinity purified
Format
Aqueous buffer solution
Formulation
PBS containing 0.05% azide and 0.05% ProClin 300
Concentration
50 µg/167 µl
Immunogen
recombinant protein
Background
LSD1 (lysine specific demethylase 1, UniProt/Swiss–Prot entry O60341) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono– and dimethylated Lys–4 of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating Lys–9 of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore mediates different processes such as embryonic development, cell differentiation and proliferation, stem and cancer cell biology.