Anti–HDAC1 monoclonal antibody

Catalog #
25286
$415 *
Size: 50 µg
Qty
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Description

Monoclonal antibody raised in mouse against human HDAC1 (Histone deacetylase 1), using a KLH–conjugated synthetic peptide containing a sequence from the C–terminal region of the protein

Synonyms
HD1, RPD3, RPD3L1, GON–10, HDAC-1
Product Info
Storage and Usage
Citations
Isotype
IgG1
Clonality
monoclonal
Host Species/Expression System
Mouse
Purification
Purified by ammonium sulphate precipitation followed by dialysis.
Format
Aqueous buffer solution
Formulation
PBS containing 0.02% thimerosal
Concentration
50 µg/25 µl
Immunogen
synthetic peptide
Background
HDAC1 (UniProt/Swiss–Prot entry Q13547) catalyses the deacetylation of lysine residues on the N–terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is associated with gene repression. Histone deacetylation is established by the formation of large multiprotein complexes. HDAC1 also interacts with the retinoblastoma tumor suppressor protein and is able to deacetylate p53. Therefore, it plays an essential role in cell proliferation and differentiation and in apoptosis