Anti-GITR Agonist Antibody

Catalog #: 79053-1
Size: 50 µg
Catalog #: 79053-2
Size: 100 µg
Host Species: HEK293
MW: Heavy Chain: 51 kDa, Light Chain: 26 kDa
Tag(s): none
Clonality: Monoclonal
Isotype: IgG1
Anti-GITR recombinant human agonist antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.
glucocorticoid-induced TNF-related ligand, AITRL, CD357L, tumor necrosis factor ligand superfamily member 18, TNFSF18
Assay Conditions:
Inhibition of GITR:GITRL interaction with anti-GITR antibody (BPS Bioscience,#79053) through GITR:GITRL TR-FRET Assay Kit (BPS Bioscience #79054). Data in the graphs are expressed as FRET ratios.
8 mM Na Phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl and 20% glycerol
Protein A affinity chromatography from HEK293 supernatants.
Storage / Stability:
Stable for at least 12 months at -80°C. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
This antibody crosslinked with FcGR2B is useful for activation of GITR costimulatory pathway in T cells
1. Cohen, A., et al., Cancer Research. 2006 May; 66(9): 4904-4912.

2. Scumpia, P.O., et al., Blood. 2007 Oct; 110(10):3673-3681.

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