AMSH Core Domain, His-tag Recombinant
Catalog #
81081
$410
*
●
●
Purchase
Description
Human AMSH Core Domain recombinant protein, a.a. 250–424, with His-tag, expressed in E. coli.
●
Synonyms
Associated molecule with the SH3 domain of STAM, STAMBP, MGC126516, MGC126518, STAM-binding protein
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Format
Aqueous buffer solution
MW
20.5 kDa
Amino Acids
250–424
UniProt #
Q96FJ0
Background
AMSHcore (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSHcore mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. AMSHcore contains only the core domain of AMSH protein.
References
1. McCullough, J., et al. AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol, 2004. 166(4): p. 487-92.
2. McCullough, J., et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2):p. 160-5.
2. McCullough, J., et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol, 2006. 16(2):p. 160-5.
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.