Alvespimycin HCl (17-DMAG)

Catalog #

27730-1

$165 *

Size: 25 mg

Qty

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Description

Alvespimycin HCl, also known as 17-DMAG, is a potent, water-soluble HSP90 inhibitor. Alvespimycin has diverse anti-tumor actions and has potential in treating a number of different types of cancers, including ovarian, prostate, melatnoma, non-small-cell lung cancer, and several leukemias (chronic lymphocytic, acute myeloid). This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway.

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Synonyms

17-DMAG; KOS-1022; NSC707545; 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin

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Product Data Gallery

Chemical Structure

Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Format

Solid

Target(s)

HSP90

Formula

C₃₂H₄₈N₄O₈ • HCl

653.21 Da

Solubility

≥26.2 mg/ml in DMSO; insoluble in EtOH; ≥3.04 mg/mL in H₂O For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.

Biological Activity

17-DMAG is an inhibitor of Hsp90 with IC50 value of 62±29 nM.

CAS Registry #

467214-21-7

Background

Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

References

1. Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126.
2. Lancet JE, et al. 2010 Apr;24(4):699-705.

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Alvespimycin HCl (17-DMAG)

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