ALK4 (ACV1B), GST-tag Recombinant

Catalog #

40020

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human activin receptor-like kinase 4, or ALK4 (a.a. 150-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_004302.

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Synonyms

ACVR1B, SKR2, ACTRIB, ACVRLK4

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

64 kDa

Amino Acids

150–end

Genbank #

NM_004302

UniProt #

P36896

Tag(s)

N-terminal GST-tag

Background

ALK4 is a member of the subfamily of receptor ser/thr kinases that mediates signaling by the Activins. ALK4 is expressed in many human tissues, including kidney, pancreas, brain, lung, and liver. Truncated ALK4, predominantly expressed in human pituitary adenomas, function as dominant negative receptors to interfere with wild-type receptor function and blocks the antiproliferative effect of activin possibly contributing to development of human pituitary tumors (1). ALK4 is able to mediate Nodal signaling in the presence of Cripto during vertebrate development (2).

References

1. Zhou, Y. et al . Mol Endocrinol. 2000 Dec;14(12):2066-75.
2. Reissmann, E. et al. Genes Dev. 2001 Aug 1;15(15):2010-22.

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ALK4 (ACV1B), GST-tag Recombinant

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