ALK1 Kinase Assay Kit

Catalog #: 79549
Size: 96 reactions
$495
Background:
ALK1, also known as activin receptor-like kinase 1 (ACVRL1) is a type I receptor from the TGF-β family of transmembrane serine/threonine kinases. Mutation of ALK1 is seen to play a role in pulmonary arterial hypertension (PAH), Osler-Weber-Rendu syndrome, and vascular smooth muscle cell development.
Description:

The ALK1 Kinase Assay Kit is designed to measure ALK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.

Materials Required But Not Provided:

ADP-Glo® Kinase Assay (Promega #V6930)

Dithiothreitol (DTT, 1 M; optional)

Microplate reader capable of reading luminescence

Adjustable micropipettor and sterile tips

30°C incubator

Synonym(s):
activin receptor-like kinase 1, ACVRL1
Supplied As:
The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Format:

Storage / Stability:
Up to 6 months when stored as recommended
Application(s):
Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications
Reference(s):
Cunha, Sara I., and Kristian Pietras. “ALK1 as an Emerging Target for Antiangiogenic Therapy of Cancer.” Blood 117(26): 6999–7006 (2011).
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Kinase
Product Type:
Assay Kit
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Product Datasheets

79549.pdf