AGK2

Catalog #: 27228
Size: 5 mg
$135
MW: 434.3 Da
CAS Registry #: 304896-28-4
Formula: C23H13Cl2N3O2
Description:
AGK2 is a selective, cell-permeable inhibitor of SIRT2. It has minimal effects SIRT1 and SIRT3 at 10-fold higher levels compared to SIRT2. Useful for studing SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.
Purity:

≥98% by HPLC

Biological Activity:
AGK2 inhibits SIRT2 with an IC50 value of 3.5 ┬ÁM.
Solubility:
Soluble in DMSO and DMF purged with an inert gas. Solubility is approximately 1 mg/ml in DMSO and approximately 3 mg/ml in DMF.
Format:
A crystalline solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Outeiro, T.F., et al., Science. 2007;317:516-519.
Scientific Category:
HDAC
Product Type:
Inhibitor
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Product Datasheets

27228_Lot120628.pdf