KAT5 (TIP60), GST-Tag

Catalog #: 79422
Size: 10 µg
$370
Species: Human
Host Species: Sf9 insect cells using baculovirus
MW: 88 kDa
Genbank #: NM_006388
Tag(s): N-terminal GST-tag
Background:
KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2).
Description:
Full-length recombinant Human KAT5 (TIP60) protein also known as cPLA2 ESA1 HTATIP, HTATIP1, PLIP, and TIP. Genbank Accession NM_006388, with an N-terminal GST tag expressed by baculovirus in Sf9 insect cells. MW = 88kDa.
Synonym(s):
cPLA2 interacting protein ESA1 HTATIP, HTATIP1, PLIP, TIP
Formulation:
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Storage / Stability:

At least 6 months at –80°C. Avoid freeze/thaw cycles.

Application(s):
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Reference(s):

1. Kamine, J. et.al. Virology.  1996; 216: 357-366.

2. Gorrini, C. et al. Nature. 2007 448:1063-1067.

Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Acetyltransferase
Product Type:
Protein
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79422.pdf