ABT-888 (Veliparib)

Catalog #

27101

$280 *

Size: 10 mg

Qty

Bulk/Custom

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Description

ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2. In the MX-1 breast xenograft model (BRCA1 deletion and BRCA2 mutation), ABT-888 potentiated cisplatin, carboplatin, and cyclophosphamide, causing regression of established tumors, whereas with comparable doses of cytotoxic agents alone, only modest tumor inhibition was exhibited.

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Synonyms

Veliparib

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥99% by HPLC

Format

White to beige powder.

Formula

C₁₃H₁₆N₄O

244.3 Da

Solubility

Soluble in DMSO.

Biological Activity

ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Ki of 5.2 nmol/L and 2.9 nmol/L, respectively. ABT-888 inhibited PARP-1 with IC50 of 4.4 nM using BPS Bioscience PARP1 Chemiluminescent Assay Kit (Cat. #80551).

CAS Registry #

912444-00-9

References

1. Donawho, C. K., et al., Clinical Cancer Research May 2007 13; 2728.
2. Sanchez, E. V., et al., Meeting: 2009 ASCO Annual Meeting. Citation: J Clincal Oncol. 27: 15s, 2009 (suppl; abstr 11028).
3. Liu, SK., et al., Radiother Oncol. 2008 Aug; 88(2): 258-68.

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ABT-888 (Veliparib)

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