Catalog #: 27057
Size: 10 mg
MW: 360.4 Da
CAS Registry #: 844499-71-4
Formula: C20H12N2O3S

A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an αβγ heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the β1 subunit. A-769662 activates AMPK through the β subunit carbohydrate-binding module and the γ subunit but not the AMP-binding sites. A-769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM.



Soluble in DMSO at 33 mg/ml; soluble in ethanol at 5 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 ┬ÁM.
White solid or off white solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
1. Scott, J.W., et al. Chem. Biol. 15: 1220-1230 (2008).
2. Cool, B., et al. Cell Metab. 3: 403-416 (2006).
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