A-769662

Catalog #: 27057
Size: 5 mg
$75
MW: 360.4 Da
CAS Registry #: 844499-71-4
Formula: C20H12N2O3S
Description:

A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an αβγ heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the β1 subunit. A-769662 activates AMPK through the β subunit carbohydrate-binding module and the γ subunit but not the AMP-binding sites. A-769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 µM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 µM.

Purity:

≥99%

Solubility:
Soluble in DMSO at 33 mg/ml; soluble in ethanol at 5 mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 ┬ÁM.
Format:
White solid or off white solid.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Scott, J.W., et al. Chem. Biol. 15: 1220-1230 (2008).
2. Cool, B., et al. Cell Metab. 3: 403-416 (2006).
Scientific Category:
Kinase
Product Type:
Inhibitor
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Product Datasheets

27057_Lot140415_R.pdf